<p>Experimentally determined K<sub>d</sub> values were compared to predicted scores using two tests: the Pearson correlation coefficient (R) and the area under the curve (AUC). The Pearson correlation coefficient is reported only for interactions with 1 nM < K<sub>d</sub> < 5,000 nM. In the AUC test, the interactions were divided into two classes: strong interactions (K<sub>d</sub> < 250 nM) and weak/non-interactions (K<sub>d</sub> ≥ 5,000 nM). The number of interactions used in each test is given in parentheses at the top of each column.</p><p><sup>a</sup> Vinson and colleagues measured coupling energies for pairs of residues in <b>a<sub>i</sub></b>-<b>a<i>'</i><sub>i</sub></b> and <b>g<sub>i</sub></b>-<b>e<i>'</i><sub>i+1</sub></b> positions. An additional empirical coupling energy of -2 kcal/mol for Leu-Leu interaction at <b>d<sub>i</sub></b>-<b>d<i>'</i><sub>i</sub></b> positions was added to account for these strongly stabilizing interactions, as in [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004046#pcbi.1004046.ref016" target="_blank">16</a>].</p><p>Benchmark of existing methods for predicting coiled-coil specificity.</p
