<p>Prediction of the known critical residues of HokC is shown for a perfect predictor (filled cyan circles) and a random predictor (open black circles). The different circles correspond to the variation on the reliability of these predictions when 20% of the 25 critical residues identified in this and previous studies were considered ISPAs (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0118288#sec002" target="_blank">Methods</a>). These predictors generate an ordered list of residues and the x-axis indicates the percentage of critical residues taken from the top of these lists. A) Plots in the Y-axis the sensitivity, B) plots in the Y-axis the specificity and C) plots in the Y-axis the Mathews Correlation Coefficient. The image was generated using gnuplot.</p
