Glucocorticoid effect on thrombinuria and proteinuria and thrombinuria vs. proteinuria or estimated glomerular filtration rate.

Abstract

<p>(<b>A</b>) Thrombinuria (left panel) and proteinuria and hematuria (right panel) before (pre) and after (post) steroid pulse treatment in 6 patients with crescentic glomerulonephritis (CresGN) (#1 to #6) with thrombinuria. Three days of pulse therapy with intravenous methylprednisolone at 0.5–1 g/day was followed by oral prednisolone at 20–30 mg/day. gCr indicates gram of urinary creatinine. (<b>B</b>) Relation between urinary thrombin and urinary protein levels for various types of glomerulonephritis. Each circle represents an individual patient. (<b>C</b>) Relation between excretion level of thrombin and estimated glomerular filtration rate (eGFR) for various types of glomerulonephritis. Each circle represents an individual patient. IgAN, IgA nephropathy; MPGN, membranoproliferative glomerulonephritis; MCNS, minimal change glomerulopathy; FSGS, focal segmental glomerulosclerosis; and MN, membranous glomerulopathy. In (<b>B</b>) and (<b>C</b>), asterisks (*) and solid lines indicate statistically significant associations and correlation lines, respectively.</p

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