<p>Healthy C57BL / 6J mice were divided into control and JCM5805 groups (n = 4 in each group), and mice in the JCM5805 group were orally administered JCM5808 daily for 2 weeks. A. Low density cells prepared from PP of each group were analyzed by FACS. Expression level of cell surface activation marker was evaluated for MHC class II as median fluorescence intensities (M.F.I.) in left panel. Ratio of pDCs to total population was shown in right panel. pDCs was defined as “CD3<sup>−</sup> Siglec-H<sup>+</sup> CD11c<sup>+</sup> in total population”. Short line represents the mean values. *<i>P</i><0.05 (Student’s t test). B, Total mRNA was extracted from PP pDCs from mice in the control (open columns) and JCM5805 groups (dot columns) (n = 8 in each group). <i>Ifnα</i> and <i>Ifnβ</i> gene expressions were measured by qRT-PCR and normalized to <i>Gapdh</i> gene expression. Data are shown as mean ± SD. *<i>P</i><0.05 (Student’s t test). These data are representative of three independent experiments. Each data are mean ± SD.</p
