<p>Vascular density of tumors in early and late stage tumors as determined by Endomucin staining. The number of mice used for analyses were as following: 8 weeks; MMTV-PyMT; Mmp8 wild-type (WT, n = 4), MMTV-PyMT; Mmp8 heterozygote (HET, n = 5), MMTV-PyMT; Mmp8 null (KO, n = 5), and 10 weeks; MMTV-PyMT; Mmp8 wild-type (WT, n = 4), MMTV-PyMT; Mmp8 heterozygote (HET, n = 6) and MMTV-PyMT; Mmp8 null (KO, n = 4). Representative pictures of 10 week tumors are shown.* p < 0.05, ** p < 0.01.</p
