Syntheses of Arnottin
I and Arnottin II
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Abstract
Short
total syntheses of arnottin I and II were accomplished in
5 and 6 steps, respectively. A sesamol-benzyne cycloaddition with
a 3-furyl-benzoate followed by regiospecific lactonization provided
rapid, large-scale access to the core of arnottin I. Saponification
of arnottin I and hypervalent iodide mediated spirocyclization provided
an efficient and direct preparation of racemic arnottin II