Multiple sequence alignment.

Abstract

<p>Sequence homologues of Lpg0393 were identified by HHpred, and its non-redundant close relatives were aligned to a set of 10 distant Vps9 domains in the PF02204 of the Pfam database. Jalview was used for rendering. The secondary structure of Rabex-5 (PDB entry: 2OT3) and the predicted secondary structure of Lpg0393 are shown at the bottom of the alignment. Two key residues for the GEF activity of Rabex-5 and AtVps9a are coloured white on red. The aligned sequences are represented by a name of species. <i>Legionella shakespearei</i> (<i>Ls</i>; UPI000377E818), <i>Legionella longbeachae</i> (<i>Ll</i>; D3HLE8), <i>Legionella drancourtii</i> LLAP 12 (<i>Ld</i>; G9ET11), <i>Legionella tunisiensis</i> (<i>Lt</i>; UPI0002ECA82A), <i>Fluoribacter dumoffii</i> (<i>Fd</i>; UPI00026C7A1A), <i>Albugo laibachii</i> Nc14 (<i>Al</i>; F0WZN8), <i>Danio rerio</i> (<i>Dr</i>; F1QIZ1), <i>Entamoeba dispar</i> (<i>Ed</i>; entry code = B0EDB3), <i>Entamoeba histolytica</i> (<i>Eh</i>; C4LYL6), <i>Micromonas</i> sp. (<i>Ms</i>; C1E5E9), <i>Nematostella vectensis</i> (<i>Nv</i>; A7SBH6), and <i>Trichomonas vaginalis</i> (<i>Tv</i>; A2DH58).</p