Ferrocene and Triazole-Appended Rhodamine Based Multisignaling
Sensors for Hg<sup>2+</sup> and Their Application in Live Cell Imaging
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Abstract
Two
triazole-appended ferrocene–rhodamine conjugates, C<sub>47</sub>H<sub>45</sub>N<sub>7</sub>O<sub>3</sub>Fe (<b>2</b>) and C<sub>49</sub>H<sub>49</sub>N<sub>7</sub>O<sub>3</sub>Fe (<b>3</b>), have been synthesized, and their electrochemical, optical,
and metal cation sensing properties have been explored in aqueous
medium. The newly synthesized receptors are simple, easily synthesizable,
and display very high “turn on” fluorescence response
for Hg<sup>2+</sup> as well as I<sup>–</sup> in an aqueous
environment. Quantification of the absorption titration analysis shows
that the receptors <b>2</b> and <b>3</b> can detect the
presence of Hg<sup>2+</sup> even at very low concentrations (∼3
ppb). The mode of metal coordination has been studied by DFT calculations.
Furthermore, the receptors <b>2</b> and <b>3</b> are less
toxic toward MCF-7 cells and could detect intracellular Hg<sup>2+</sup> by fluorescent imaging studies