Design, Synthesis, and Characterization of SO<sub>2</sub>‑Containing Azabicyclo[3.<i>n</i>.1]alkanes:
Promising Building Blocks for Drug Discovery
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Abstract
A set
of novel SO<sub>2</sub>-containing azabicyclo[3.<i>n</i>.1]alkanes has been synthesized by the double-Mannich annulation
of of the corresponding monocyclic S-ketones. These compounds have
been rationally designed as 3D-shaped, conformationally restricted
SO<sub>2</sub>-containing building blocks for drug discovery
