An Enantioselective Approach to Functionalized Amino Acids: Total Synthesis of Antiepileptic Drug (<i>R</i>)‑Lacosamide

Abstract

A short and highly efficient synthetic approach to enantiopure functionalized amino acids (FAAs) <b>1</b> skeleton from racemic butadiene monoepoxide as a starting material and its application to the total synthesis of an antiepileptic drug (<i>R</i>)-lacosamide <b>2</b> are described. The synthesis utilizes the palladium catalyzed Trost’s Dynamic Kinetic Asymmetric Transformation (DYKAT) as key step