Fluorescent Gold Nanodots Based Sensor Array for Proteins
Discrimination
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Abstract
A series
of dual-ligand cofunctionalized fluorescent gold nanodots
with similar fluorescence and diverse surface properties has been
designed and synthesized to build a protein sensing array. Using this
“chemical nose/tongue” strategy, fluorescence response
patterns can be obtained on the array and identified via linear discriminant
analysis (LDA). Eight proteins have been well distinguished at low
concentration (<i>A</i><sub>280</sub> = 0.005) based on
this sensor array. The practicability of this sensor array was further
validated by high accuracy (100%) examination of 48 unknown protein
samples