The redundancy test and the parameter sensitivity analysis of the MAPK signaling networks.
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Abstract
<p>(A) Two pathways from (EGF-EGFR*)<sub>2</sub>-GAP to (EGF-EGFR*)<sub>2</sub>-GAP-Grb2-Sos are both Shc independent. The blue and green curves indicate that removing either path has similar impact on the concentration of ERK-PP. (B) The sensitivity analysis for the reaction generating (EGF-EGFR*)<sub>2</sub>-GAP. A small change in the reaction rate has a big effect on the output signal. A bifurcation is observed when k18 is less than 2.1e-5. (C) Sensitivity analysis of the binding rate of Ras-GDP to (EGF-EGFR*)<sub>2</sub>-GAP-Grb2-Sos. (D) Sensitivity analysis of the binding rate of Ras-GDP to (EGF-EGFR*)<sub>2</sub>-GAP-Shc*-Grb2-Sos. Another bifurcation is observed at the rate 2.0e-0.5.</p
