Probing the Interactions of Intrinsically Disordered
Proteins Using Nanoparticle Tags
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Abstract
The structural plasticity of intrinsically
disordered proteins serves as a rich area for scientific inquiry.
Such proteins lack a fix three-dimensional structure but can interact
with multiple partners through numerous weak bonds. Nevertheless,
this intrinsic plasticity possesses a challenging hurdle in their
characterization. We underpin the intermolecular interactions between
intrinsically disordered neurofilaments in various hydrated conditions,
using grafted gold nanoparticle (NP) tags. Beyond its biological significance,
this approach can be applied to modify the surface interaction of
NPs for the creation of future tunable “smart” hybrid
biomaterials