New Meroterpenoids from <i>Aspergillus terreus</i> with Inhibition of Cyclooxygenase‑2 Expression
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Abstract
Two novel meroterpenoids,
yaminterritrems A (<b>1</b>) and
B (<b>2</b>), were isolated from <i>Aspergillus terreus</i> collected from hot spring zones in Yang-Ming Mountain, Taiwan, and
cultured at 40 °C. The structures of <b>1</b> and <b>2</b> were elucidated by NMR, MS spectral and X-ray crystallographic
analyses. The biosynthetic route for <b>1</b> and <b>2</b> involving the conversion of the sesquiterpene with phenyl-α-pyrone
is proposed. Besides, <b>2</b> exhibited a dose-dependent inhibitory
effect on COX-2 expression in LPS-stimulated RAW264.7 macrophages