New Meroterpenoids from <i>Aspergillus terreus</i> with Inhibition of Cyclooxygenase‑2 Expression

Abstract

Two novel meroterpenoids, yaminterritrems A (<b>1</b>) and B (<b>2</b>), were isolated from <i>Aspergillus terreus</i> collected from hot spring zones in Yang-Ming Mountain, Taiwan, and cultured at 40 °C. The structures of <b>1</b> and <b>2</b> were elucidated by NMR, MS spectral and X-ray crystallographic analyses. The biosynthetic route for <b>1</b> and <b>2</b> involving the conversion of the sesquiterpene with phenyl-α-pyrone is proposed. Besides, <b>2</b> exhibited a dose-dependent inhibitory effect on COX-2 expression in LPS-stimulated RAW264.7 macrophages