Dual-Stimuli-Responsive Nanoassemblies as Tunable
Releasing Carriers
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Abstract
Two
end-decorated homopolymers, methoxy polyethylene glycol-ferrocene
(mPEG-Fc) and poly(<i>N</i>-isopropylacrylamide)-β-cyclodextrin
(PNIPAM-β-CD), were further orthogonally self-assembled into
stable micelles in aqueous solution by controlling the temperature
of the solution via terminal host–guest interactions. Because
of the H<sub>2</sub>O<sub>2</sub> cleavable
CD/Fc connection and thermoresponsive PNIPAM, an H<sub>2</sub>O<sub>2</sub> and thermo dual-controlled
drug release based on this system was also achieved. Interestingly,
the cytotoxicity evaluation of mPEG-Fc/PNIPAM-β-CD indicated
good biocompatibility. Compared with free doxorubicin, the doxorubicin-loaded
supramolecular micelles exhibited equal cellular proliferation inhibition
toward A549 cells. This supramolecular complex is thus anticipated
to serve as a promising new type of alternative drug-delivery system
