Flavonoids
from Matteuccia struthiopteris and
Their Anti-influenza Virus (H1N1) Activity
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Abstract
Seven new flavonoid glycosides (<b>1</b>–<b>7</b>), matteflavosides A–G, together
with 12 known flavonoids
(<b>8</b>–<b>19</b>) were isolated from the rhizomes
of Matteuccia struthiopteris (L.) Todar.
Their structures were established via the analyses of extensive spectroscopic
data. All compounds were evaluated for their anti-influenza virus
(H1N1) activity using the neuraminidase inhibition assay. The results
showed that compound <b>7</b> exhibited significant inhibitory
activity against the H1N1 influenza virus neuraminidase with an EC<sub>50</sub> value of 6.8 ± 1.1 μM and an SI value of 34.4,
and compounds <b>8</b> and <b>17</b> showed moderate inhibitory
activity