<p>A) The TTR monomers in the dimer structure are shown as ribbons and are labeled A and B. The symmetry-related monomers are labeled A´, and B´. Two luteolin molecules bind at the thyroxin-binding channels, and are shown as sticks. For clarity, only one of the symmetry-related luteolin orientations is shown. B) The quality of the electron density map at the BB´ dimer-dimer interface. The σA-weighted (m|Fo|-D|Fc|) electron density contoured at 3 times the root-mean-square value of the map is shown in orange. To reduce model bias the luteolin molecule was excluded from the coordinate file that was subjected to one round of simulated annealing refinement before calculation of the map.</p
