Human astrocytes were converted into neurons by the miR-302/367 cluster in vitro, without pre-treatment with valproic acid (VPA).

Abstract

<p><b>(A)</b> Human induced neurons expressed neuroblast marker [doublecortin (DCX)] and neuronal markers (TUJ1 and NeuN) at 8 and 10 days post in vitro (DPI) when they received the miR-302/367 cluster. <b>(B)</b> Quantification of immunostaining data provided in A. Scale bar: 50 μm.</p