Abstract

<p><i>Pain</i>: <i>mechanical non-noxious and noxious stimuli</i>. a) The Von Frey test was used to measure the pain threshold as a response evoked by a non-noxious stimulus. b) Paw-pressure test was used to measure sensitivity to a mechanical noxious stimulus. <i>Motor coordination</i>. The integrity of the animals’ motor coordination was assessed using a Rota-rod apparatus measuring c) the time spent to keep the balance and d) the number of falls, in 600 s. Animals were treated daily i.p. with 2.4 mg kg<sup>-1</sup> oxaliplatin or vehicle. PEA (30 mg kg<sup>-1</sup>) was administered daily i.p. Behavioral evaluations were performed on day 21, 24h after treatment (pre) and 60 min after a new injection. Control animals were treated with vehicles. Each value represents the mean of 12 rats per group, performed in two different experimental sets. **P<0.01 versus vehicle + vehicle; ^P<0.05 and ^^P<0.01 versus oxaliplatin + vehicle.</p

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