Highly Enantioselective and <i>Anti</i>-Diastereoselective Catalytic Intermolecular Glyoxylate–Ene Reactions: Effect of the Geometrical Isomers of Alkenes

Abstract

An efficient method for the synthesis of homoallylic alcohols with high enantioselectivities and <i>anti</i>-diastereoselectivities via an In­(III)-catalyzed intermolecular glyoxylate–ene reaction has been developed. The geometrical isomers of alkenes were shown to have different reactivities. Only the isomers of the alkenes having a proton β-cis to the substituent reacted in this catalytic system