<p><b>A,</b> Embryos with biallelic mutations in <i>Sbds</i> have decreased mass compared with littermate controls, **<i>P</i><4X10<sup>-6</sup>. <i>Sbds</i><sup><i>R126T/–</i></sup>embryos are smaller than <i>Sbds</i><sup><i>R126T/R126T</i></sup> embryos, *<i>P</i> = 1.9X10<sup>-4</sup> (Wilcoxon Rank Sum Test; Kruskal-Wallis <i>P</i> = 3.0X10<sup>-8</sup>). Error bars represent ±SEM. Scale bar represents 5 mm (upper panel). <b>B,</b> Decreased granulocytes (dark purple, H&E, E18.5) in liver (cell cluster examples are indicated with yellow arrowheads) and bone marrow (black arrowheads) with loss of <i>Sbds</i>; N = 3 (<i>Sbds</i><sup><i>R126T/R126T</i></sup>) and 4 (<i>Sbds</i><sup><i>R126T/–</i></sup>). Scale bars represent 100 μm. <b>C,</b> Decreased bone ossification was observed in transverse metacarpal sections of mutants (corresponding regions of littermate controls that maintain red Safranin O staining in mutants are highlighted with magenta arrowheads, E18.5). Scale bars represent 100 μm.</p
