Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived <i>Streptomyces spinoverrucosus</i>

Abstract

Spithioneines A and B (<b>1</b> and <b>2</b>), two new bohemamine-type pyrrolizidine alkaloids possessing an unusual ergothioneine moiety, were isolated from a marine-derived <i>Streptomyces spinoverrucosus</i>. Their structures were elucidated by spectroscopic analysis, CD spectra, and chemical degradation and synthesis. Compounds <b>1</b> and <b>2</b> are rare natural products that incorporate the amino acid ergothioneine