A Chlorin-Based
Nanoscale Metal–Organic Framework
for Photodynamic Therapy of Colon Cancers
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Abstract
We
report here the rational design of the first chlorin-based nanoscale
metal–organic framework (NMOF), DBC-UiO, with much improved
photophysical properties over the previously reported porphyrin-based
NMOF, DBP-UiO. Reduction of the DBP ligands in DBP-UiO to the DBC
ligands in DBC-UiO led to a 13 nm red shift and an 11-fold increase
in the extinction coefficient of the lowest-energy Q band. While inheriting
the crystallinity, stability, porosity, and nanoplate morphology of
DBP-UiO, DBC-UiO sensitizes more efficient <sup>1</sup>O<sub>2</sub> generation and exhibits significantly enhanced photodynamic therapy
(PDT) efficacy on two colon cancer mouse models as a result of its
improved photophysical properties. Both apoptosis and immunogenic
cell death contributed to killing of cancer cells in DBC-UiO-induced
PDT