Teotihuacanin, a Diterpene with an Unusual Spiro-10/6
System from <i>Salvia amarissima</i> with Potent Modulatory
Activity of Multidrug Resistance in Cancer Cells
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Abstract
Teotihuacanin (<b>1</b>), an
unusual rearranged clerodane
diterpene with a new carbon skeleton containing a spiro-10/6 bicyclic
system, was isolated from the leaves and flowers of <i>Salvia
amarissima</i>. Its structure was determined through spectroscopic
analyses. Its absolute configuration was established by single-crystal
X-ray diffraction. Compound <b>1</b> showed potent modulatory
activity of multidrug resistance in vinblastine-resistant MCF-7 cancer
cell line (reversal fold, RF<sub>MCF‑7/Vin+</sub> > 10703)
at 25 μg/mL