Domino One-Pot Process for the Synthesis of Isobenzofuran-1(3<i>H</i>)‑ones via [Cu]-Catalysis Using Water as the Green Solvent

Abstract

An efficient domino one-pot strategy via [Cu]-catalyzed intermolecular “cyanation” of <i>o</i>-bromobenzyl alcohols → in situ intramolecular “nucleophilic attack” → “hydrolysis” is presented, for the synthesis of isobenzofuran-1­(3<i>H</i>)-ones. Significantly, the reaction is successfully carried out under environmentally benign conditions, using water as sole green solvent