Domino One-Pot Process
for the Synthesis of Isobenzofuran-1(3<i>H</i>)‑ones
via [Cu]-Catalysis Using Water as the Green
Solvent
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Abstract
An efficient domino one-pot strategy
via [Cu]-catalyzed intermolecular
“cyanation” of <i>o</i>-bromobenzyl alcohols
→ in situ intramolecular “nucleophilic attack”
→ “hydrolysis” is presented, for the synthesis
of isobenzofuran-1(3<i>H</i>)-ones. Significantly, the reaction
is successfully carried out under environmentally benign conditions,
using water as sole green solvent