Copper-/Cobalt-Catalyzed Highly Selective Radical Dioxygenation of Alkenes

Abstract

A highly selective radical dioxygenation of alkenes using hydroxamic acid and O₂ was developed, and copper/cobalt was used as the catalyst without assistance of any additional ligands or bases. Mechanistic investigation disclosed that copper salt and O₂ work in concert to activate hydroxamic acid, with Cu­(I) and Cu­(II) concurrently existing in this reaction