Antiproliferative Trihydroxyalkylcyclohexenones from <i>Pleiogynium timoriense</i>

Abstract

Investigation of a DCM extract of the bark of <i>Pleiogynium timoriense</i> from the former Merck collection of natural product extracts for antiproliferative activity indicated that it was active with an IC₅₀ value of 1.3 μg/mL against the A2780 ovarian cancer cell line. Bioassay-directed fractionation of this extract yielded the three new bioactive trihydroxyalkylcyclohexenones <b>1</b>–<b>3</b>. Their structures were determined by a combination of spectroscopic and chemical methods. Compounds <b>1</b>–<b>3</b> exhibited submicromolar antiproliferative activity against the A2780 human ovarian cancer cell line, with IC₅₀ values of 0.8, 0.7, and 0.8 μM, respectively