Ligand-Free Pd-Catalyzed
Double Carbonylation of Aryl Iodides with Amines to α‑Ketoamides
under Atmospheric Pressure of Carbon Monoxide and at Room Temperature
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Abstract
A general
Pd-catalyzed double carbonylation of aryl iodides with
secondary or primary amines to produce α-ketoamides at atmospheric
CO pressure has been developed. This transformation proceeds successfully
even at room temperature and in the absence of any ligand and additive.
A wide range of aryl iodides and amines can be coupled to the desired
α-ketoamides in high yields with excellent chemoselectivities.
Importantly, the current methodology has been demonstrated to be applied
in the synthesis of bioactive molecules and chiral α-ketoamides