Total Synthesis of (−)‑<i>N</i>‑Methylwelwitindolinone C Isothiocyanate Based on a Pd-Catalyzed Tandem Enolate Coupling Strategy
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Abstract
The
highly stereocontrolled total synthesis of (−)-<i>N</i>-methylwelwitindolinone C isothiocyanate is described,
which features the expeditious construction of a bicyclo[4.3.1]decane
ring system by a palladium-catalyzed tandem enolate allylation/arylation
reaction