LbL Assembly of Albumin on Nitric Oxide-Releasing
Silica Nanoparticles Using Suramin, a Polyanion Drug, as an Interlayer
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Abstract
Preformed protein corona of nanoparticles
can be utilized as a
promising formulation strategy for improving nano drug delivery. Nitric
oxide (NO) is a labile molecule with extensive therapeutic implications.
In this study, we test whether preformation of protein coatings can
enhance the performance of NO-delivering nanoparticles. S-Nitroso
(SNO) silica nanoparticles (SNO-SiNPs) were prepared using a nanoprecipitation
method. For the first time, bovine serum albumin (BSA) was used to
coat NO-releasing nanoparticles, facilitated by a polyanionic drug,
suramin, under a layer-by-layer (LbL) scheme. Bare and coated nanoparticles
were characterized by zeta-potential, size, and spectroscopic measurements.
We demonstrate that albumin/suramin-surface coassembly has advantages
in preventing particle aggregation during lyophilization, controlling
NO release and exerting an enhanced anticancer effect