Copper-Mediated Oxidative Coupling of Benzamides with
Maleimides via Directed C–H Cleavage
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Abstract
A Cu(OAc)<sub>2</sub>/Cy<sub>2</sub>NMe-mediated oxidative direct coupling of benzamides
with maleimides has been developed. The aromatic C–H alkenylation
with the aid of an 8-aminoquinoline-based bidentate directing group
is followed by an intramolecular aza-Michael-type addition to form
the isoindolone-incorporated spirosuccinimides, which are of potent
interest in medicinal chemistry
