Cystochromones, Unusual Chromone-Containing Polyketides
from the Myxobacterium <i>Cystobacter</i> sp. MCy9104
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Abstract
Seven new chromone-containing polyketides,
termed cystochromones
A–G, were isolated from the myxobacterial strain <i>Cystobacter</i> sp. MCy9104. Their structures were elucidated using comprehensive
NMR spectroscopy and HR-MS/MS. Cystochromones bear a pentadecyl moiety
unusually attached at C-5 of the chromone ring. Moreover, isotope-labeled
substrate feeding experiments and NMR analysis suggested a hybrid
iso-fatty acid and polyketide synthase biosynthetic pathway for these
secondary metabolites