Kadcoccinic Acids A–J, Triterpene Acids from <i>Kadsura coccinea</i>

Abstract

Eleven triterpene acids including 10 new compounds (kadcoccinic acids A–J, <b>1</b>–<b>10</b>) were isolated from the stems of <i>Kadsura coccinea</i>. Except for <b>10</b>, these compounds feature a rearranged lanostane skeleton with a 6/6/5/6 tetracyclic ring system, and compounds <b>1</b> and <b>2</b> are the first examples of 2,3-<i>seco</i>-6/6/5/6-fused tetracyclic triterpenoids. Their structures were established primarily by spectroscopic and spectrometric methods. Additionally, the absolute configuration of <b>3</b> was determined by single-crystal X-ray diffraction. Several of the compounds isolated were tested for their anti-HIV-1 and cytotoxic activities