The synthesis of the core motif of
branched poly(adenosine diphosphate
ribose) (poly(ADPr)) is described, and structural analysis reasserted
the proposed stereochemistry for branching. For the synthesis, a ribose
trisaccharide was first constructed with only α-<i>O</i>-glycosidic linkages. Finally, the adenine nucleobase was introduced
via a Vorbrüggen-type glycosylation reaction. The orthogonality
of the selected protecting groups was demonstrated, allowing for the
construction of branched poly(ADPr) oligomers in the near future
