Evaluation of cytotoxic and genotoxic activities in the bone marrow of mice treated with sulfonamide chalcone N-{4-[3-(4-nitrophenyl)prop-2-enoyl]phenyl}-benzenesulfonamide (CPN) based on MNPCE and PCE/NCE frequency.
<p><sup>1</sup> Negative control: dimethylsulfoxide (DMSO) 0.1 mL/10 g body weight (b.w.).</p><p><sup>2</sup> Positive control: mitomycin C (MMC) 4 mg/kg (80% LD<sub>50</sub>).</p><p>All values are mean ± SD of five mice.</p><p><sup>3</sup> Statistical analysis: one-way ANOVA and the Tukey’s test.</p><p><sup>4</sup> Statistical analysis: chi-square (χ<sup><b>2</b></sup>) test.</p><p>Mean values followed by the same letter in the column do not present significant difference at 5% probability.</p><p><sup>a, b, c, d</sup> Letter in common in the same column do not present significant difference (<i>p</i> > 0.05). Different letters in the same column present significant difference (<i>p</i> < 0.05).</p><p>Evaluation of cytotoxic and genotoxic activities in the bone marrow of mice treated with sulfonamide chalcone N-{4-[3-(4-nitrophenyl)prop-2-enoyl]phenyl}-benzenesulfonamide (CPN) based on MNPCE and PCE/NCE frequency.</p
