Blood Components Interactions to Ionic and Nonionic
Glyconanogels
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Abstract
Nanogels
are prominent examples of “smart” nanomaterials,
which are designed to incorporate biologically relevant (macro)molecules
for systemic delivery. Although these systems are carefully engineered,
only a handful of studies discuss the blood compatibility of nanogels,
and no systematic studies are available on how the presence of net
or surface charges impacts the hemocompatibility of these nanomaterials.
Therefore, in this study, temperature responsive, galactose based
nanogels bearing net positive, negative, or neutral charges, either
in the core or shell of nanogels, are prepared and are subsequently
evaluated for their blood compatibility profiles. The nanogels containing
neutral core and shell, cationic core with neutral shell, anionic
core with neutral shell, neutral core with cationic shell, and neutral
core with anionic shell are prepared by reversible addition–fragmentation
chain transfer (RAFT) polymerization approach. The evaluation of complement
activation, blood clot formation, platelet activation, red blood cells
aggregation, and hemolysis provides a detailed analysis of structure
activity relationship of blood compatibility profile of these nanogels.
The data reveal that the physical and biological (blood compatibility)
properties can be carefully tuned by embedding the charges in the
core of temperature-responsive nanomaterials, protected by neutral
carbohydrate based shells