Stereoselective Synthesis of d‑5-Homo-4-selenoribose as a Versatile Intermediate for 4′-Selenonucleosides

Abstract

Stereoselective synthesis of d-5-homo-4-selenoribose, serving as a versatile intermediate for the synthesis of 4′-selenonucleosides <b>12a</b>–<b>c</b>, was accomplished using Sharpless asymmetric epoxidation, regioselective cleavage of the α,β-epoxide, and stereoselective reduction of the ketone as the key steps