Wiek, Robert Jago

English

Functional properties of the Drosophila FCO (femoral chordotonal organ) can be dissected
by use of the Gal4-UAS system in combination with transcuticular in vivo Calcium
imaging. As sinusoidal stimulation at relative small stimulus amplitudes elicited
changes in intracellular ionic calcium (Ca2+) concentration in the FCO, the effect of
substrate vibration on Drosophila walking behaviour was proposed. But lately developed
fly tracking software for high-throughput ethomics (Branson et al., 2009) showed that
substrate vibrations have no specific effect on Drosophila walking behaviour. Instead
present evidence suggests that Drosophila compensates for substrate vibration by
detection via the FCO and therefore is able to control its body posture. A modification of transcuticular in vivo Calcium imaging was used to locate the neuronal activity region of
Inactive, a protein involved in Drosophila hearing and a mechanotransduction channel
candidate. Here I show that Inactive mutants still respond to sound like stimulation
with ciliary calcium currents

Georg-August-University Göttingen

A Functional Characterisation of Drosophila Chordotonal Organs

https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0001-B986-9/1/Robert%20Wiek_A%20Functional%20Characterization%20of%20Drosophila%20Chordotonal%20Organs_2013.pdf

A Functional Characterisation of Drosophila Chordotonal Organs

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Georg-August-University Göttingen