One-Pot Synthesis of 1,3-Bis(phosphinomethyl)arene
PCP/PNP Pincer Ligands and Their Nickel Complexes
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Abstract
A one-pot
synthesis of arene-based PCP/PNP ligands has been developed.
The reaction of 1,3-bis(bromomethyl)benzene or 2,6-bis(bromomethyl)pyridine
with various chlorophosphines in acetonitrile afforded bis-phosphonium
salts. These salts can then be reduced by magnesium powder to yield
PCP or PNP ligands. In comparison to traditional synthetic methods
for making PCP/PNP ligands involving the use of secondary phosphines,
this new alternative method allows for the use of chlorophosphines,
which are cheaper, safer to handle, and have a broader range of commercially
available derivatives. This is especially true for the chlorophosphines
with less bulky alkyl groups. Moreover, the one-pot procedure can
be extended to allow for the direct synthesis of PCP/PNP nickel complexes.
By using nickel powder as the reductant, the resulting nickel halide
was found to directly undergo metalation with the PCP or PNP ligand
to generate nickel complexes in high yields