Synthesis of Novel Nucleoside
Analogues Built on a
Bicyclo[4.1.0]heptane Scaffold
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Abstract
A new
class of carbocyclic nucleoside analogues built on a bicyclo[4.1.0]heptane
scaffold, a perspective novel pseudosugar pattern, have been conceived
as anti-HSV agents on the basis of initial protein–ligand docking
studies. The asymmetric synthesis of a series of these compounds incorporating
different nucleobases has been efficiently completed starting from
1,4-cyclohexanedione