Selective Access to 4‑Substituted 2‑Aminothiazoles
and 4‑Substituted 5-Thiocyano-2-aminothiazoles from Vinyl Azides
and Potassium Thiocyanate Switched by Palladium and Iron Catalysts
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Abstract
A highly selective construction of
4-substituted 2-aminothiazoles
and 4-substituted 5-thiocyano-2-aminothiazoles, respectively, catalyzed
by palladium(II) acetate and promoted by iron(III) bromide from vinyl
azides and potassium thiocyanate has been developed. Use of readily
available starting materials, high selectivity, as well as mild reaction
conditions make this practical method particularly attractive