Ruthenium-Catalyzed
Enantioselective Hydrogenation
of Ferrocenyl Ketones: A Synthetic Method for Chiral Ferrocenyl Alcohols
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Abstract
Highly
effective asymmetric hydrogenation of various ferrocenyl
ketones, including aliphatic ferrocenyl ketones as well as the more
challenging aryl ferrocenyl ketones, was realized in the presence
of a Ru/diphosphine/diamine bifunctional catalytic system. Excellent
enantioselectivities (up to 99.8% ee) and activities (S/C = 5000)
could be obtained. These asymmetric hydrogenations provided a convenient
and efficient synthetic method for chiral ferrocenyl alcohols, which
are key intermediates for a variety of chiral ferrocenyl ligands and
resolving reagents