Indium(III) Chloride-Catalyzed Isocyanide Insertion
Reaction to Construct Complex Spirooxindole
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Abstract
An unusual multiple isocyanide insertion
reaction with methyleneindolinone
using indium(III) chloride as the catalyst has been disclosed. This
strategy allows for the rapid construction of structurally complex
spirooxindole in an efficient manner. The present protocol features
mild conditions, atom economy, and broad substrate scope