Nickel-Catalyzed Regioselective Cross-Dehydrogenative Coupling of Inactive C(sp³)–H Bonds with Indole Derivatives

Abstract

A nickel-catalyzed regiosepecific C2- versus C3-oxidative cross-coupling reaction of indoles with 1,4-dioxane and other inactive C­(sp³)–H bonds is described. The divergent synthesis of C­(sp³)–C­(sp²) bonds was achieved in satisfactory yields with di-<i>tert</i>-butyl peroxide (DTBP) as the oxidant, which provides an efficient strategy for the selective construction of cyclic ethers containing heteroaromatic core structures