Arg1 is induced in inflamed musculoskeletal tissues and in blood leukocytes but not lymphoid tissues of RRV- and CHIKV-infected mice.

Abstract

<p>WT mice were mock-inoculated (n = 5) or inoculated with 10³ PFU of (A) RRV (n = 6) or (B) CHIKV (n = 6). At 10 dpi the gastrocnemius muscle (“Muscle”), ankle/foot joint (“Joint”), circulating blood leukocytes (“Blood”), bone marrow (“BM”) from the femur, the draining popliteal LN (“pLN”), and the spleen were harvested for RT-qPCR analysis of <i>Arg1</i> expression. Data are combined from two independent experiments, normalized to 18S rRNA levels, and are expressed as the relative expression (<i>n</i>-fold increase) over expression in each tissue from mock-inoculated mice. Each data point represents the arithmetic mean ± SEM. ** <i>P</i> < 0.01, * <i>P</i> < 0.05 as determined by significance test of greater than one.</p