<div><p>Two new chalcones, 2′,3,4,4′-tetrahydroxy-2-prenylchalcone (<b>1</b>) and 3-methoxy-2′,4,4′-trihydroxy-2-prenylchalcone (<b>2</b>), together with two known compounds, munsericin (<b>3</b>) and 3,4-dihydroxylonchocarpin (<b>4</b>), were isolated from the ethanol extract of the whole plant of <i>Shuteria sinensis</i>. Their structures were identified by spectroscopic analysis methods, such as 1D and 2D NMR, along with HR-MS data. Glucose metabolism activity of four compounds was tested, compounds <b>3</b> and <b>4</b> showed effect on the glucose consumption of insulin-resistant HepG2 cells.</p></div
