A new antifungal labdane diterpene from the leaves of <i>Saraca indica</i>

Abstract

<div><p>A new labdane diterpene, along with 10 known sterols and flavonoids, was isolated from the hydroalcoholic extract of the leaves of <i>Saraca indica</i>. The chemical structure of the new compound was identified as 6,9-epoxy marrubiinic acid on the basis of spectroscopic analyses including two-dimensional NMR. The antimicrobial potential of the new compound was evaluated against Gram-positive and Gram-negative bacteria as well as fungi. It showed a significant antifungal activity against <i>Geotric</i><i>h</i><i>um candidum</i> with MIC 0.48 μg/mL. It also showed potential cytotoxicity against human cancer cell lines with IC<sub>50</sub> ranging from 1.07 to 1.29 μg/well.</p></div

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