Magnetically Multilayer Polysaccharide Membranes for
Biomedical Applications
- Publication date
- Publisher
Abstract
Self-standing
nanocomposite films based on biopolymers and functional
nanostructures have been widely used due to their potential applications
as active elements in biomedical devices. The coupling between chitosan
(CHI) and alginate (ALG) multilayered films and magnetic nanoparticles
(MNPs) allowed to fabricate magnetic responsive freestanding membranes
with a high structural control along the thickness, using the layer-by-layer
(LbL) methodology. The mechanical characterization evidenced a trend
for an increase of both Young modulus, and ultimate tensile strength
with the inclusion of MNPs, or by cross-linking with genipin. Additionally,
the multilayered membranes exhibited shape memory properties triggered
by hydration. The in vitro biological performance studies showed that
cells were more viable and adherent with higher proliferation rates
when MNPs were included in the membranes. Our results suggested the
potential of the developed magneto-active freestanding membranes for
biomedical applications, such as in tissue engineering and biomedical
applications