Thermodynamic Analysis of Allosteric and Chelate Cooperativity
in Di- and Trivalent Ammonium/Crown-Ether Pseudorotaxanes
- Publication date
- Publisher
Abstract
A detailed thermodynamic
analysis of the axle-wheel binding in
di- and trivalent secondary ammonium/[24]crown-8 pseudorotaxanes is
presented. Isothermal titration calorimetry (ITC) data and double
mutant cycle analyses reveal an interesting interplay of positive
as well as negative allosteric and positive chelate cooperativity
thus providing profound insight into the effects governing multivalent
binding in these pseudorotaxanes